Have an account? Log in to check out faster.
Active B vitamins your body can actually use, in the forms it absorbs best.
Serving Size: 1 Tablet · Servings per Container: 30
| Per Serving | %RI* | |
|---|---|---|
| Riboflavin (B2) as Riboflavin-5 Phosphate | 30 mg | 2,143% |
| Niacin (B3) as nicotinamide | 100 mg | 625% |
| Vitamin B6 as Pyridoxal 5-Phosphate | 10 mg | 713% |
| Folate as L-5-Methyltetrahydrofolate | 667 µg | 334% |
| Vitamin B12 as methylcobalamin | 500 µg | 20,000% |
| Biotin as D-Biotin | 900 µg | 1,800% |
| Pantothenic Acid (B5) | 100 mg | 1,667% |
| Benfotiamine | 75 mg | ** |
| Inositol | 10 mg | ** |
| BioPerine® Black Pepper Extract providing 1.9 mg Piperine | 2 mg | ** |
*Reference Intake (RI) for an average adult **No RI established
Reference Intake (RI), also called the Nutrient Reference Value (NRV), is a single general figure for an average adult, set under UK food-labelling rules so products can be compared like for like. It reflects an amount considered enough for the great majority of healthy people rather than a personalised or optimal target, which is why supplement levels are often shown as a high percentage of the RI. Individual needs vary, so use the RI as a guide alongside a varied, balanced diet.
Suggested Use: Take 1 tablet daily, preferably with a meal.
Our active ingredients are backed by 200+ published clinical studies, including 135 randomised controlled trials and 29 meta-analyses. We choose every active for the research behind it, not because it is on trend. Here are a few of the studies on the B vitamins and active forms we use.
In the FACIT trial, 818 older adults took 800µg of folic acid every day for 3 years and scored on memory tests like people about 4.7 years younger than their age. Folate only helps if the body can use it, which is why we deliver it as L-5-MTHF (methylfolate), the active form, rather than folic acid. Folate contributes to normal psychological function.
Durga J et al. The Lancet, 2007.
In a double-blind trial, healthy adults taking a daily vitamin supplement for 12 months reported better mood than those on placebo, measured across the whole group. Mood relies on B vitamins like B6, folate and B12, which we include in their active forms (P5P, methylfolate and methylcobalamin). B6, folate and B12 contribute to normal psychological function.
Benton D et al. Neuropsychobiology, 1995.
Benfotiamine is a fat-soluble form of thiamine (B1) that the body takes up far more easily than the standard thiamine used in most supplements. In a pharmacokinetic study it raised blood thiamine to around 11 times the level from standard thiamine hydrochloride. Thiamine contributes to normal energy-yielding metabolism and the normal function of the heart and nervous system.
Pharmacokinetic study, benfotiamine vs thiamine hydrochloride, 2014.
In the University of Oxford VITACOG trial, older adults with mild cognitive impairment who took B vitamins (folate, B6 and B12) showed on average around 30% less brain atrophy over two years than those given a placebo, with the greatest benefit in those with raised homocysteine.
Smith AD et al. PLoS ONE, 2010.
Many people carry a common variation in the MTHFR gene that slows how they process folate. In a double-blind trial, riboflavin (vitamin B2) lowered homocysteine in people with this 677TT gene type, by about 22% across the group and by as much as 40% in those who started with lower riboflavin levels. We include riboflavin as its active R5P form. Riboflavin and folate contribute to normal homocysteine metabolism.
McNulty H et al. Circulation, 2006.
A meta-analysis pooling 25 randomised trials found folic acid lowered homocysteine by about 23%. We deliver folate (vitamin B9) as L-5-MTHF (methylfolate), the active form the body uses directly, without the conversion step folic acid needs. Folate contributes to normal homocysteine metabolism.
Wald DS et al. Am J Clin Nutr, 2005.
One-time purchase, no subscription.
Published clinical research on these B vitamins, and why we deliver them in their active, methylated forms, not a generic B-complex.
Backed by 200+ clinical studies
younger memory
after 3 years
FACIT, double-blind, 818 adults
memoryIn the FACIT trial, 818 older adults took 800µg of folic acid every day for 3 years and scored on memory tests like people about 4.7 years younger. Our formula provides folate (vitamin B9) too, but as L-5-MTHF (methylfolate), the active form the body can use directly without first converting it. Folate contributes to normal psychological function.
FACIT trial · double-blind, randomised · Durga et al., The Lancet, 2007
mood, over 12 months
Benton et al., 1995, double-blind
moodIn a double-blind trial, healthy adults taking a daily vitamin supplement for 12 months reported better mood than those on placebo, measured across the whole group. Mood relies on B vitamins like B6, folate and B12, which we include in their active forms, P5P, methylfolate and methylcobalamin. B6, folate and B12 contribute to normal psychological function.
Benton et al. · double-blind, placebo-controlled · 1995
better absorbed
vs standard vitamin B1
Benfotiamine PK study, vs thiamine HCl
energyBenfotiamine is the fat-soluble form of vitamin B1, and the body takes it up far more easily than the cheap thiamine used in most supplements. In a pharmacokinetic study it raised blood thiamine to roughly 11 times the level from standard thiamine hydrochloride (a relative bioavailability of 1147%). It's the form we use. Thiamine (B1) contributes to normal energy-yielding metabolism.
Pharmacokinetic study · benfotiamine vs thiamine hydrochloride · PMID 24399744
less brain shrinkage
over 2 years
Oxford VITACOG, double-blind
brainIn Oxford University's VITACOG trial, older adults with raised homocysteine took folic acid, vitamin B6 and B12 for 2 years and had about 30% less brain shrinkage than those on placebo. Our formula includes the same three B vitamins, folate (B9), B6 and B12, in their active forms (methylfolate, P5P and methylcobalamin). These B vitamins contribute to normal homocysteine metabolism.
Oxford VITACOG · double-blind, randomised · Smith et al. 2010; Douaud et al. 2013
lower homocysteine
with the common MTHFR gene type
McNulty et al., 2006, MTHFR 677TT
methylationLots of people carry a common variation in the MTHFR gene that slows how their body handles folate. In a double-blind trial, riboflavin (vitamin B2) lowered homocysteine in people with this 677TT gene type, by about 22% across the group and by as much as 40% in those who started with lower riboflavin levels. We include riboflavin as its active R5P form. Riboflavin and folate contribute to normal homocysteine metabolism.
McNulty et al. · Circulation, 2006 · double-blind · MTHFR 677TT adults
lower homocysteine
across 25 randomised trials
Wald et al., 2005, meta-analysis
methylationA meta-analysis pooling 25 randomised trials found that folic acid lowered homocysteine by about 23%. Our formula delivers folate (vitamin B9) as L-5-MTHF (methylfolate), the active form the body uses directly, without the conversion step folic acid needs. Folate contributes to normal homocysteine metabolism.
Wald et al. · meta-analysis of 25 randomised trials · 2005
Results from published clinical studies on the active nutrients and forms we use, not claims about the finished product. Food supplements are not a substitute for a varied, balanced diet and a healthy lifestyle.
See how Prime Vitality compares.
who feel the difference every day.
"Ordered these for my husband and me a few weeks ago and we have both noticed a real difference in our energy. Ordering more soon."
"My partner and I both feel much more energetic after a few weeks. So much better than the store multivitamins. Buying again."
"I did not realise I was low in B12 until I started these. Ten weeks on and I feel so much better, more energy, more focus, up and ready for the day."
"I was tired most of the time. Taking this every morning I am not constantly tired anymore. A massive difference."
"My energy just feels better. I am not as tired through the day and I am getting more done without thinking about it."
"I had been feeling flat all the time. Since taking this my energy has picked up and I feel sharper, more like myself again."
"I have tried loads of supplements and most end up in the cupboard. This is one of the few I have stuck with. I feel more focused and sharper day to day."
"Excellent product. After a few weeks I have a lot more energy in the afternoons, which I really needed. Will buy again."
"Really impressed. I cannot believe how much these have helped me. Thank you to the Prime team for answering my questions."
"Really like these. I feel more awake and focused since I started taking them each morning."
"These have become part of my daily routine and I feel really good for it. So pleased I found a quality B complex made in Britain."
"A month in and I can honestly feel the difference. I have more energy through the day and feel really good taking them."
"Four months in and I feel great taking these every day. I have even got my husband on them too. Really happy with them."
"Good quality B vitamins and the team were really helpful with all of my questions. Thank you."
"I had been struggling with tiredness for a while. A few weeks on these and I have more energy and feel more like myself again."
"I didn't expect much but after a week or so I noticed I wasn't as exhausted by the end of the day. Just feels easier to get through things."
"I've tried a few supplements before and never stuck with them. This is one of the first where I've actually felt a difference, mainly with energy."
"Mornings used to be a struggle but they feel a bit smoother now. Not a huge change, just more consistent which I like."
"I've been taking it for about 3 weeks and feel less foggy at work. I'm getting through tasks quicker without overthinking everything."
"It's been good so far. I do feel a bit more energy and less drained, just wish I'd noticed it a bit sooner."
"Energy feels more level throughout the day. I'm not getting that dip in the afternoon like I used to."
"I bought this after feeling constantly tired and it's helped more than I expected. I just feel a bit more like myself again."
"Didn't expect much but after a couple of weeks I noticed I was a lot less tired after work. Small change but it's made a difference day to day."
"I mainly bought it for energy but I've actually felt a bit more focused as well. Just feel a bit more on it, especially in the mornings."
"It's good, definitely feel a bit more energy and less foggy. Not a massive change but enough that I'll keep taking it."
"I've been using this for about a month and I just feel more balanced. Hard to explain but I'm not as drained by the end of the day."
"I train a lot and normally feel wiped after work, but this has helped keep my energy more consistent. Doesn't feel like a stimulant, which I like."
"I was a bit sceptical but I do feel better on this. Less sluggish in the mornings and I don't rely on coffee as much."
"Honestly didn't expect to notice anything but I actually have. Feel a bit sharper and not as forgetful during the day."
"I've tried cheaper ones before and never noticed a difference. This one feels cleaner somehow, energy is just more even."
"Been taking it for a few weeks now and I'd say I just feel better overall. More energy and a bit more motivation to get things done."
"It's alright. I do feel a bit more energy and slightly less foggy, just not as much as I was hoping for. I'll probably finish the bottle and see how it goes."
"I didn't expect much if I'm honest. But I've been a bit less forgetful at work and just feel a bit sharper overall."
"I've been using it for a couple of months now. It's quite subtle but I feel more balanced, especially with energy. I'm not relying on coffee as much."
"It's decent. I've noticed a bit more energy and focus, just not as much as I hoped. Still better than others I've tried though."
"I bought this after a friend mentioned it. Took a week or so but I do feel less tired in the mornings. Getting up is a bit easier now."
"I train most days and work full time, so I'm usually knackered. This has helped take the edge off that constant tired feeling."
"I've tried cheaper B vitamins and never felt anything. This one feels different, hard to explain but I just feel more switched on."
"Been taking it for about 3 weeks. Energy is more stable and I'm not dipping in the afternoon like before."
"I'm quite sceptical with supplements but this has surprised me. I feel more alert during the day and less drained after work."
"I've been using it just over a month. I'd say the main difference is I don't feel as run down. It's subtle but definitely there."
"I normally hit a wall around 3pm. That's eased off quite a bit since starting this, which has been really helpful with work."
"I've stuck with this longer than anything else I've tried. I just feel a bit more clear headed and less foggy."
"Didn't think I'd notice anything but I actually have. Energy feels smoother and not up and down like before."
"I've been taking it for 6 weeks now. Looking back, I was more tired than I realised. I've definitely got more about me now."
"I like that it doesn't feel like a stimulant. Just gives me a bit more energy to get through the day without feeling wired."
"Mornings are a lot easier now. I used to feel really slow getting going, but that's improved quite a bit."
"I've tried loads of things for energy and this is one of the few I've actually noticed. Nothing crazy, just feel better overall."
Real results. Real people.
Targeted nutrients. Proven benefits.
Built from lived experience. Backed by better ingredients.
It started with a simple question: why do so many supplements promise the world but leave you feeling exactly the same?
After years of trying generic B-complex products and not feeling a difference, I set out to build a formula using the active, methylated forms of B vitamins your body can actually use.
Every batch is made in Britain to high quality standards, vegan, non-GMO, and designed for real life: one tablet, once a day.
Jackson, Founder
Produced in facilities independently certified to globally recognised quality, food-safety and environmental standards.
Prime Vitality only works with manufacturers held to the highest standards, so the quality you take every day is never left to chance.
Targeted ingredients. Purposeful doses.
Supports energy metabolism.
Supports energy and normal skin.
Helps reduce tiredness and fatigue.
Supports mental performance.
Supports hormones and the nervous system.
Supports methylation and energy.
Supports energy and focus.
Supports hair and skin.
A B-vitamin companion nutrient.
Patented piperine extract.
Simple. Daily. Consistent.
Take one tablet once daily.
Helps with absorption and reduces the chance of stomach upset.
Take one tablet every day and make it part of your routine, backed by our up-to-90-day money-back guarantee.
Pick your plan and start today.
Choose my plan ↑Clear answers. Real confidence.
Methylated means the vitamins are in their active forms, which are easier for your body to recognise, absorb and use. This can be especially beneficial for those with gene variations that affect vitamin activation.
Prime Vitality was created from real, lived experience. Every B vitamin is in its fully active, methylated form and made in the UK in GMP-certified facilities. Many brands use basic, non-active forms that your body has to convert before it can use them. We start with the forms your body can use straight away.
Cheaper supplements use non-active, basic forms that cost very little to produce. Prime Vitality uses premium active forms, like benfotiamine (B1), methylcobalamin (B12), L-5-MTHF folate and P5P (B6), which cost more but are already in the state your body can use. You are paying for quality that reaches your cells, not fillers.
Take one tablet daily, ideally with a meal. Morning is a great time, as B vitamins contribute to normal energy-yielding metabolism throughout the day.
Take one tablet once daily.
Helps with absorption and reduces the chance of stomach upset.
For best results, use daily for at least 3 months.
Yes. Prime Vitality Methylated B Complex Ultra is fully vegan and non-GMO.
Yes. Every batch is manufactured in Britain, in facilities that are independently certified to recognised quality and food-safety standards.
Subscribe & Save comes in two options. Quarterly is the best value: 3 jars auto-delivered every 3 months at 40% off, just 50p a day. Monthly sends 1 jar every month at 24% off, for maximum flexibility. Both let you skip, change or cancel anytime from your account, and both are covered by our 90-day money-back guarantee.
