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A premium, high-strength methylated B complex, made in Britain. All eight B vitamins in their active forms, including the methylated forms of B12 and folate (methylcobalamin and L-methylfolate), plus P5P and benfotiamine, a fat-soluble derivative of thiamine with 11x the bioavailability of standard thiamine. Expertly formulated around the active forms studied in published research, by a proudly British company you can trust. One small tablet a day: vegan, non-GMO and gluten-free.
Serving Size: 1 Tablet · Servings per Container: 30
| Per Serving | %RI* | |
|---|---|---|
| Riboflavin (B2) as Riboflavin-5 Phosphate | 30 mg | 2,143% |
| Niacin (B3) as nicotinamide | 100 mg | 625% |
| Vitamin B6 as Pyridoxal 5-Phosphate | 10 mg | 713% |
| Methylfolate (B9) as L-5-Methyltetrahydrofolate | 667 µg | 334% |
| Methylcobalamin (B12) as methylcobalamin | 500 µg | 20,000% |
| Biotin as D-Biotin | 900 µg | 1,800% |
| Pantothenic Acid (B5) | 100 mg | 1,667% |
| Benfotiamine | 75 mg | ** |
| Inositol | 10 mg | ** |
| BioPerine® Black Pepper Extract providing 1.9 mg Piperine | 2 mg | ** |
*Reference Intake (RI) for an average adult **No RI established
Reference Intake (RI), also called the Nutrient Reference Value (NRV), is a single general figure for an average adult, set under UK food-labelling rules so products can be compared like for like. It reflects an amount considered enough for the great majority of healthy people rather than a personalised or optimal target, which is why supplement levels are often shown as a high percentage of the RI. Individual needs vary, so use the RI as a guide alongside a varied, balanced diet.
Suggested Use: Take 1 tablet daily, preferably with a meal.
Our active ingredients are backed by 200+ published clinical studies, including 135 randomised controlled trials and 29 meta-analyses. We choose every active for the research behind it, not because it is on trend. Here are a few of the studies on the B vitamins and active forms we use.
In the FACIT trial, 818 older adults took 800µg of folic acid every day for 3 years and scored on memory tests like people about 4.7 years younger than their age. Folate only helps if the body can use it, which is why we deliver it as L-5-MTHF (methylfolate), the active form, rather than folic acid. Folate contributes to normal psychological function.
Durga J et al. The Lancet, 2007.
In a double-blind trial, healthy adults taking a daily vitamin supplement for 12 months reported better mood than those on placebo, measured across the whole group. Mood relies on B vitamins like B6, folate and B12, which we include in their active forms (P5P, methylfolate and methylcobalamin). B6, folate and B12 contribute to normal psychological function.
Benton D et al. Neuropsychobiology, 1995.
Benfotiamine is a fat-soluble form of thiamine (B1) that the body takes up far more easily than the standard thiamine used in most supplements. In a pharmacokinetic study it raised blood thiamine to around 11 times the level from standard thiamine hydrochloride. That superior absorption is why we use it in place of the cheap thiamine salts most supplements rely on.
Pharmacokinetic study, benfotiamine vs thiamine hydrochloride, 2014.
In the University of Oxford VITACOG trial, older adults with mild cognitive impairment who took B vitamins (folate, B6 and B12) showed on average around 30% less brain atrophy over two years than those given a placebo, with the greatest benefit in those with raised homocysteine.
Smith AD et al. PLoS ONE, 2010.
Many people carry a common variation in the MTHFR gene that slows how they process folate. In a double-blind trial, riboflavin (vitamin B2) lowered homocysteine in people with this 677TT gene type, by about 22% across the group and by as much as 40% in those who started with lower riboflavin levels. We include riboflavin as its active R5P form. Riboflavin and folate contribute to normal homocysteine metabolism.
McNulty H et al. Circulation, 2006.
A meta-analysis pooling 25 randomised trials found folic acid lowered homocysteine by about 23%. We deliver folate (vitamin B9) as L-5-MTHF (methylfolate), the active form the body uses directly, without the conversion step folic acid needs. Folate contributes to normal homocysteine metabolism.
Wald DS et al. Am J Clin Nutr, 2005.
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Published research on the active, methylated B vitamins we use, in the forms your body absorbs best.
Backed by 200+ clinical studies
younger memory
after 3 years
FACIT, double-blind, 818 adults
memoryIn the FACIT trial, 818 older adults took 800µg of folic acid every day for 3 years and scored on memory tests like people about 4.7 years younger. Our formula provides folate (vitamin B9) too, but as L-5-MTHF (methylfolate), the active form the body can use directly without first converting it. Folate contributes to normal psychological function.
FACIT trial · double-blind, randomised · Durga et al., The Lancet, 2007
mood, over 12 months
Benton et al., 1995, double-blind
moodIn a double-blind trial, healthy adults taking a daily vitamin supplement for 12 months reported better mood than those on placebo, measured across the whole group. Mood relies on B vitamins like B6, folate and B12, which we include in their active forms, P5P, methylfolate and methylcobalamin. B6, folate and B12 contribute to normal psychological function.
Benton et al. · double-blind, placebo-controlled · 1995
better absorbed
vs standard vitamin B1
Benfotiamine PK study, vs thiamine HCl
energyBenfotiamine is the fat-soluble derivative of thiamine, and the body takes it up far more easily than the cheap thiamine used in most supplements. In a pharmacokinetic study it raised blood thiamine to roughly 11 times the level from standard thiamine hydrochloride (a relative bioavailability of 1147%). It's the form we use, chosen for that superior absorption.
Pharmacokinetic study · benfotiamine vs thiamine hydrochloride · PMID 24399744
less brain shrinkage
over 2 years
Oxford VITACOG, double-blind
brainIn Oxford University's VITACOG trial, older adults with raised homocysteine took folic acid, vitamin B6 and B12 for 2 years and had about 30% less brain shrinkage than those on placebo. Our formula includes the same three B vitamins, folate (B9), B6 and B12, in their active forms (methylfolate, P5P and methylcobalamin). These B vitamins contribute to normal homocysteine metabolism.
Oxford VITACOG · double-blind, randomised · Smith et al. 2010; Douaud et al. 2013
lower homocysteine
with the common MTHFR gene type
McNulty et al., 2006, MTHFR 677TT
methylationLots of people carry a common variation in the MTHFR gene that slows how their body handles folate. In a double-blind trial, riboflavin (vitamin B2) lowered homocysteine in people with this 677TT gene type, by about 22% across the group and by as much as 40% in those who started with lower riboflavin levels. We include riboflavin as its active R5P form. Riboflavin and folate contribute to normal homocysteine metabolism.
McNulty et al. · Circulation, 2006 · double-blind · MTHFR 677TT adults
lower homocysteine
across 25 randomised trials
Wald et al., 2005, meta-analysis
methylationA meta-analysis pooling 25 randomised trials found that folic acid lowered homocysteine by about 23%. Our formula delivers folate (vitamin B9) as L-5-MTHF (methylfolate), the active form the body uses directly, without the conversion step folic acid needs. Folate contributes to normal homocysteine metabolism.
Wald et al. · meta-analysis of 25 randomised trials · 2005
Results from published clinical studies on the active nutrients and forms we use, not claims about the finished product. Food supplements are not a substitute for a varied, balanced diet and a healthy lifestyle.
Why is our supplement different
Check any other label: if it says folic acid or cyanocobalamin, your body still has the conversion to do.
See how Prime Vitality compares.
Three customers, in their own words, on video.
I've been taking Prime Vitality for a couple of weeks, and the noticeable differences are huge!”
Tristan S, Croydon
I cannot tell you the difference it's made. I feel like I've had a good sleep, I wake up in the mornings with energy.”
Jacqui, West Yorkshire
My energy is on another level, especially later in the day.”
Sutha, London
Rated 4.81 out of 5 by 215 customers
“I was tired most of the time. Taking this every morning I am not constantly tired anymore. A massive difference.”
James · Leeds
“I had been feeling flat all the time. Since taking this my energy has picked up and I feel sharper, more like myself again.”
Kyle D. · Birmingham
“These have become part of my daily routine and I feel really good for it. So pleased I found a quality B complex made in Britain.”
Sue H. · Manchester
Targeted nutrients. Proven benefits.
Built from lived experience. Backed by better ingredients.
It started with a simple question: why do so many supplements promise the world but leave you feeling exactly the same?
After years of trying generic B-complex products and not feeling a difference, I set out to build a formula using the active, methylated forms of B vitamins your body can actually use.
Every batch is made in Britain to high quality standards, vegan, non-GMO, and designed for real life: one tablet, once a day.
Jackson, Founder
Produced in facilities independently certified to recognised quality and food-safety standards.
Prime Vitality only works with manufacturers held to the highest standards, so the quality you take every day is never left to chance.
Targeted ingredients. Purposeful doses.
Premium, better-absorbed form.
Supports energy and normal skin.
Helps reduce tiredness and fatigue.
Supports mental performance.
Supports hormones and the nervous system.
Supports methylation and energy.
Supports energy and focus.
Supports hair and skin.
A B-vitamin companion nutrient.
Patented piperine extract.
Simple. Daily. Consistent.
Take one tablet once daily.
Helps with absorption and reduces the chance of stomach upset.
Take one tablet every day and make it part of your routine, backed by our up-to-90-day money-back guarantee.
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Methylated means the vitamins are in their active forms, which are easier for your body to recognise, absorb and use. Some people carry common gene variations that affect how efficiently they make that conversion.
Prime Vitality was created from real, lived experience. Every B vitamin is in its fully active, methylated form and made in Britain in GMP-certified facilities. Many brands use basic, non-active forms that your body has to convert before it can use them. We start with the forms your body can use straight away.
Cheaper supplements use non-active, basic forms that cost very little to produce. Prime Vitality uses premium active forms, like benfotiamine, methylcobalamin (B12), L-5-MTHF folate and P5P (B6), which cost more but are already in the state your body can use. You are paying for quality that reaches your cells, not fillers.
That is riboflavin, vitamin B2, and it is completely normal. Riboflavin is a naturally bright yellow-green pigment: its name comes from flavus, the Latin word for yellow. Ours is Riboflavin-5-Phosphate, the active form.
B vitamins are water soluble, so your body uses what it needs and passes the rest out rather than storing it. Riboflavin gives that a vivid yellow tint, usually within a few hours of taking your tablet. Doctors have a name for it, flavinuria, and it is harmless and well documented.
It is expected with any B-complex at a meaningful dose, and it is not a sign that anything is wrong. As with any supplement, if you have another symptom that concerns you, speak to your GP or pharmacist.
Take one tablet daily, ideally with a meal. Morning is a great time, as B vitamins contribute to normal energy-yielding metabolism throughout the day.
Take one tablet once daily.
Helps with absorption and reduces the chance of stomach upset.
For best results, use daily for at least 3 months.
Yes. Prime Vitality Methylated B Complex Ultra is fully vegan and non-GMO.
Yes. Every batch is manufactured in Britain, in facilities that are independently certified to recognised quality and food-safety standards.
Subscribe & Save delivers 3 jars every 3 months at 40% off, which works out at 50p a day. You can skip, change or cancel any time from your account, and it is covered by the same 90-day money-back guarantee.
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