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Methylated B vitamins in a high-strength, active B complex: one small vegan tablet a day.
Every meal has to be turned into energy your body can actually use. B vitamins do that work, all day, every day, and ours come in the active forms your body can use straight away.
Riboflavin (B2), niacin (B3), pantothenic acid (B5), vitamin B6, vitamin B12 and biotin contribute to normal energy-yielding metabolism.
Food supplements should not replace a varied, balanced diet and a healthy lifestyle.
Running out of steam by mid-afternoon? Six of the B vitamins in this one small tablet help reduce tiredness and fatigue, including B12 and folate in their methylated forms.
Riboflavin (B2), niacin (B3), pantothenic acid (B5), vitamin B6, folate and vitamin B12 contribute to the reduction of tiredness and fatigue.
Food supplements should not replace a varied, balanced diet and a healthy lifestyle.
Your immune system works for you every single day. B6, B12 and folate help it work normally, and we use all three in their active forms: P5P B6, methylcobalamin B12 and L-methylfolate, ready for your body to use.
Vitamin B6, folate and vitamin B12 contribute to the normal function of the immune system.
Food supplements should not replace a varied, balanced diet and a healthy lifestyle.
Every message between your brain and your body travels along your nerves. Five of the B vitamins in this tablet help keep that system working as it should.
Riboflavin (B2), niacin (B3), vitamin B6, vitamin B12 and biotin contribute to the normal functioning of the nervous system.
Food supplements should not replace a varied, balanced diet and a healthy lifestyle.
Your mind does a lot of work every day. Five of the B vitamins in this tablet support it, with folate and B12 in their methylated forms, the forms your body can use right away.
Niacin (B3), vitamin B6, folate, vitamin B12 and biotin contribute to normal psychological function.
Food supplements should not replace a varied, balanced diet and a healthy lifestyle.
Red blood cells carry oxygen to every part of your body. B6, B12 and folate help your body make them normally, and riboflavin helps maintain them.
Vitamin B6 and vitamin B12 contribute to normal red blood cell formation, folate contributes to normal blood formation, and riboflavin (B2) contributes to the maintenance of normal red blood cells.
Food supplements should not replace a varied, balanced diet and a healthy lifestyle.
Serving Size: 1 Tablet · Servings per Container: 30
| Per Serving | %RI* | |
|---|---|---|
| Riboflavin (B2) as Riboflavin-5 Phosphate | 30 mg | 2,143% |
| Niacin (B3) as nicotinamide | 100 mg | 625% |
| Vitamin B6 as Pyridoxal 5-Phosphate | 10 mg | 713% |
| Methylfolate (B9) as L-5-Methyltetrahydrofolate | 667 µg | 334% |
| Methylcobalamin (B12) as methylcobalamin | 500 µg | 20,000% |
| Biotin as D-Biotin | 900 µg | 1,800% |
| Pantothenic Acid (B5) | 100 mg | 1,667% |
| Benfotiamine | 75 mg | ** |
| Inositol | 10 mg | ** |
| BioPerine® Black Pepper Extract providing 1.9 mg Piperine | 2 mg | ** |
*Reference Intake (RI) for an average adult **No RI established
Reference Intake (RI), also called the Nutrient Reference Value (NRV), is a single general figure for an average adult, set under UK food-labelling rules so products can be compared like for like. It reflects an amount considered enough for the great majority of healthy people rather than a personalised or optimal target, which is why supplement levels are often shown as a high percentage of the RI. Individual needs vary, so use the RI as a guide alongside a varied, balanced diet.
Suggested Use: Take 1 tablet daily, preferably with a meal.
Our active ingredients are backed by 200+ published clinical studies, including 168 randomised controlled trials and 48 meta-analyses and systematic reviews. We choose every active for the research behind it, not because it is on trend. Here are a few of the studies on the B vitamins and active forms we use.
See all 259 studies we hold, each one checked →
In the FACIT trial, 818 older adults took 800µg of folic acid every day for 3 years and scored on memory tests like people about 4.7 years younger than their age. Folate only helps if the body can use it, which is why we deliver it as L-5-MTHF (methylfolate), the active form, rather than folic acid. Folate contributes to normal psychological function.
Durga J et al. The Lancet, 2007.
In a double-blind trial, 129 healthy young adults took a daily supplement of nine vitamins for 12 months and reported better mood than those on placebo, most clearly among the women, with the improvement tracking their rising vitamin B2 and B6 status. We include B2 and B6, with folate and B12, in their active forms (R5P, P5P, methylfolate and methylcobalamin). B6, folate and B12 contribute to normal psychological function.
Benton D et al. Neuropsychobiology, 1995.
Benfotiamine is a fat-soluble derivative of thiamine (vitamin B1) that the body takes up more easily than standard thiamine hydrochloride. In a pharmacokinetic study in healthy volunteers it raised blood thiamine to around 11 times the level reached from thiamine hydrochloride, and roughly doubled the active coenzyme form in red blood cells. That superior absorption is why we chose it.
Xie F et al. J Clin Pharmacol, 2014.
In a double-blind trial, 215 healthy working men aged 30 to 55 took a high-dose B complex (with vitamin C and minerals) every day for 33 days. Compared with placebo, they rated themselves less mentally tired after demanding mental tasks and reported more vigour. Our formula is a high-dose B complex too, with B2, B3, B5, B6, folate and B12 in their active forms. Those six B vitamins contribute to the reduction of tiredness and fatigue.
Kennedy DO et al. Psychopharmacology, 2010.
Many people carry a common variation in the MTHFR gene that slows how they process folate. In a double-blind trial, 35 adults with this 677TT gene type took riboflavin (vitamin B2) at 1.6mg a day, or a placebo, for 12 weeks; homocysteine fell by about 22% across the riboflavin group and by as much as 40% in those who started with lower riboflavin levels. We include riboflavin as its active R5P form, alongside folate, B6 and B12. Folate, B6 and B12 contribute to normal homocysteine metabolism.
McNulty H et al. Circulation, 2006.
A meta-analysis pooling 25 randomised trials found folic acid lowered homocysteine by about 23%. We deliver folate (vitamin B9) as L-5-MTHF (methylfolate), the active form the body uses directly, without the conversion step folic acid needs. Folate contributes to normal homocysteine metabolism.
Homocysteine Lowering Trialists' Collaboration. Am J Clin Nutr, 2005.
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How the plan works
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A note from our founder
There is nothing worse than a company that makes it hard to cancel. I have been on the wrong end of that myself, so here is how ours works, in plain English.
For after you've ordered: sign in with the email you used at checkout.
💌 Or email us at Hello@primevitalitydirect.com and we will sort it for you. To skip a delivery, cancel before your next billing date.
🤔Why offer a plan at all?
Not to tie you in. Most B vitamins are not stored in the body for long, so they work best taken regularly, and the studies we cite ran for months, some over a year. And honestly, most of us just forget to reorder. The plan takes that off your plate.
📦How it works
The 3-month plan is our best price, 40% off. It arrives automatically and is charged at the start of each cycle until you cancel.
Jackson, founder
Methylated B Complex Ultra is a high-strength B complex in one small vegan tablet a day.
It is built around forms of B vitamins your body can use straight away: methylated B12 and folate, B6 as P5P and B2 as Riboflavin-5-Phosphate, alongside benfotiamine, a fat-soluble form of thiamine.
Vitamins B2, B6 and B12 contribute to normal energy-yielding metabolism and to the reduction of tiredness and fatigue, and B6 and B12 contribute to the normal function of the nervous system.
Every ingredient is backed by published research, with 200+ studies on the ingredients, at doses you can see on the label. Made in Britain.
Each tablet carries the methylated forms of vitamin B12 (methylcobalamin, 500 µg) and folate (L-5-MTHF, 667 µg), the forms your body can use straight away. Vitamin B6 comes as P5P (10 mg) and vitamin B2 as Riboflavin-5-Phosphate (30 mg), their active forms.
Alongside them: benfotiamine (75 mg), a fat-soluble form of thiamine; niacin as nicotinamide (100 mg); pantothenic acid (100 mg); biotin (900 µg); inositol (10 mg) and BioPerine® black pepper extract (2 mg).
Every batch is manufactured in Britain, in GMP-certified facilities that are independently certified to recognised quality and food-safety standards.
Each tablet is vegan, non-GMO and gluten-free, and one bottle holds 30 tablets: a one-month supply.
Delivery is free across the UK, and most orders arrive by in a few days.
Every order is covered by our 90-day money-back guarantee. On the 3-month plan there is no minimum term and no fees: cancel or change online, any time.
Save £3 on one bottle. Offer ends in
Ends Thu 29 Oct, 23:59. Then back to £25.
Try a bottle for £22, backed by our 90-day money-back guarantee.
3-month supply, delivered every 3 months
Published research on the B vitamins in our formula, which we provide in their active forms.
Backed by 200+ clinical studies
younger memory scores
in a 3-year folate trial
FACIT, double-blind, 818 adults
memoryFrom middle age onwards, memory scores tend to drift down year on year, and that steady decline is exactly what the FACIT researchers measured against. In that trial, 818 adults aged 50 to 70 with raised homocysteine took 800µg of folic acid every day for three years, and finished ahead of the placebo group by roughly what 4.7 years of that decline would have cost them. Put simply: on those tests, their memory performed as though it were 4.7 years younger. Our formula provides folate (vitamin B9) too, but as L-5-MTHF (methylfolate), the active form the body can use directly without first converting it. Folate contributes to normal psychological function.
FACIT trial · double-blind, randomised · Durga et al., The Lancet, 2007 · PMID 17240287
mood, over 12 months
in a double-blind vitamin trial
Benton et al., 1995, 129 adults
moodIn a double-blind trial, 129 healthy young adults took a daily supplement of nine vitamins, at ten times the recommended daily amounts, for 12 months. Those on the vitamins reported better mood than those on placebo, most clearly among the women, and the improvement tracked their rising vitamin B2 and B6 status. We include B2 and B6, with folate and B12, in their active forms: R5P, P5P, methylfolate and methylcobalamin. B6, folate and B12 contribute to normal psychological function.
Benton et al. · Neuropsychobiology, 1995 · double-blind, placebo-controlled · PMID 7477807
better absorbed
vs standard thiamine (vitamin B1)
Xie et al., 2014, pharmacokinetic study
energyBenfotiamine is a fat-soluble derivative of thiamine (vitamin B1) that the body takes up more easily than standard thiamine hydrochloride. In a pharmacokinetic study in healthy volunteers, it raised blood (plasma) thiamine to roughly 11 times the level reached from thiamine hydrochloride (a relative bioavailability of 1147%) and roughly doubled the active coenzyme form in red blood cells. That superior absorption is why we chose it.
Xie et al. · pharmacokinetic study, benfotiamine vs thiamine hydrochloride · 2014 · PMID 24399744
mental tiredness, after 33 days
in a high-dose B complex trial
Kennedy et al., 2010, double-blind, 215 men
energyIn a double-blind trial, 215 healthy working men aged 30 to 55 took a high-dose B complex (with vitamin C and minerals) every day for 33 days. Compared with placebo, they rated themselves less mentally tired after demanding mental tasks and reported more vigour. Our formula is a high-dose B complex too, with B2, B3, B5, B6, folate and B12 in their active forms. Those six B vitamins contribute to the reduction of tiredness and fatigue.
Kennedy et al. · Psychopharmacology, 2010 · double-blind, placebo-controlled · PMID 20454891
lower homocysteine
in MTHFR 677TT adults
McNulty et al., 2006
methylationWhy a high reading is worth knowing about. Homocysteine is what is left over when your body runs methylation, the reaction it uses to build and repair everything from DNA to brain chemistry. Folate, B12 and B6 normally recycle that leftover straight back into something useful. When those vitamins run short the recycling stalls and homocysteine builds up in the blood, which is why a raised reading is treated as one of the clearest signs that someone's folate and B12 status is poor. Bringing it down is the sign that the cycle is turning over properly again. Lots of people also carry a common variation in the MTHFR gene that slows how their body handles folate. In a double-blind trial, 35 adults with this 677TT gene type took riboflavin (vitamin B2) at 1.6mg a day, or a placebo, for 12 weeks. Homocysteine fell by about 22% across the riboflavin group, and by as much as 40% in those who started with lower riboflavin levels. We include riboflavin as its active R5P form, alongside folate, B6 and B12. Folate, B6 and B12 contribute to normal homocysteine metabolism.
McNulty et al. · Circulation, 2006 · double-blind · MTHFR 677TT adults · PMID 16380544
lower homocysteine
in 25 randomised trials
Meta-analysis, 2005
methylationWhy a high reading is worth knowing about. Homocysteine is the leftover from methylation, the reaction your body uses to build and repair DNA and brain chemistry. Folate, B12 and B6 recycle that leftover back into something useful, so when they run short it builds up. That is why a raised reading is one of the clearest signs that folate and B12 status is poor, and why bringing it down shows the cycle has what it needs again. A meta-analysis pooling 25 randomised trials (2,596 people) found that folic acid lowered homocysteine by about 23% at a dose of 0.8mg a day. Our formula delivers folate (vitamin B9) as L-5-MTHF (methylfolate), the active form the body uses directly, without the conversion step folic acid needs. Folate contributes to normal homocysteine metabolism.
Homocysteine Lowering Trialists' Collaboration · meta-analysis of 25 randomised trials · American Journal of Clinical Nutrition, 2005 · PMID 16210710
Results from published clinical studies on the active nutrients and forms we use, not claims about the finished product. Food supplements are not a substitute for a varied, balanced diet and a healthy lifestyle.
Made in BritainVegan
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| Label check |  Prime VitalityMethylated B Complex Ultra | Holland & BarrettHigh Strength Complete Vit B Complex | BootsVitamin B Complex | IgennusSuper B-Complex | WeightWorldVitamin B Complex | New LeafVitamin B Complex | SolgarB-Complex “50” | BetterYouB-Complete Oral Spray | HorbäachVitamin B Complex | SolgarB-Complex “100” | BioCareMethyl B Complex |
|---|---|---|---|---|---|---|---|---|---|---|---|
One a dayOne tablet or capsule | Yes | No2 tablets | Yes | No2 tablets | Yes | Yes | Yes | No4 sprays | Yes | Yes | Yes |
BenfotiamineFat-soluble form of thiamine, better absorbed* | Yes | NoThiamine | NoThiamine | NoThiamine | NoThiamine | NoThiamine | NoThiamine | NoThiamine | NoThiamine | NoThiamine | NoThiamine |
30 mg of active B2 a dayRiboflavin-5-phosphate | Yes | No15 mg (not the active form) | No1.4 mg (not the active form) | No14 mg | No7 mg (not the active form) | No5 mg (not the active form) | No50 mg (not the active form) | No0.35 mg | No1.4 mg (not the active form) | No100 mg (not the active form) | No25 mg |
Active B6P5P, not pyridoxine | Yes | NoPyridoxine | NoPyridoxine | Yes | NoPyridoxine | NoPyridoxine | NoPyridoxine | NoPyridoxine | NoPyridoxine | NoPyridoxine | Yes |
100 mg of B5 a dayPantothenic acid | Yes | Yes | No6 mg | No36 mg | No20 mg | No9.2 mg | No50 mg | No4.5 mg | No6 mg | Yes | No25 mg |
Methylated folateL-methylfolate, not folic acid | Yes | NoFolic acid | NoFolic acid | Yes | NoFolic acid | NoFolic acid | NoFolic acid | NoFolic acid | NoFolic acid | NoFolic acid | Yes |
900 µg of biotin a day | Yes | No100 µg | No50 µg | No300 µg | No150 µg | No150 µg | No50 µg | No50 µg | No50 µg | No100 µg | No200 µg |
Swipe to compare 10 brands →
The eight best-selling B complexes on Amazon UK, plus the own-brand B complexes of Holland & Barrett and Boots, compared using each brand’s own label and website, checked 16 October 2026. Figures per daily serving. “Not the active form” means riboflavin rather than riboflavin-5-phosphate. *Benfotiamine is better absorbed than standard thiamine (Xie et al., 2014).
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Built from lived experience. Backed by better ingredients.
It started with a simple question: why did nothing I tried make a difference?
After years of trying generic B-complex products and not feeling a difference, I set out to build a formula using the active, methylated forms of B vitamins your body can use straight away.
Every batch is made in Britain to high quality standards, vegan, non-GMO, and designed for real life: one tablet, once a day.
Jackson, Founder
Produced in facilities independently certified to recognised quality and food-safety standards.
Prime Vitality only works with manufacturers held to the highest standards, so the quality you take every day is never left to chance.
What each B vitamin does, in plain English.
Targeted ingredients. Purposeful doses.
Amounts per tablet. Tap any ingredient for what it is and what it does.
What it is
What it does
Simple. Daily. Consistent.
With a glass of water.
Breakfast or lunch is easiest.
Make it part of your routine, backed by our 90-day money-back guarantee.
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Buy Now ↑Methylated B vitamins are B vitamins supplied in the forms your body can use straight away, rather than forms it has to convert first. In this formula the two methylated forms are vitamin B12 as methylcobalamin and folate as L-5-MTHF methylfolate. Vitamin B6 is supplied as P-5-P and vitamin B2 as riboflavin-5-phosphate, which are active forms rather than methylated ones.
Methylated means the vitamins are in their active forms, which are easier for your body to recognise, absorb and use. Some people carry common gene variations that affect how efficiently they make that conversion.
Yes. Vitamin B6, folate and vitamin B12 contribute to the normal function of the immune system, and our formula uses all three in their active forms: P5P B6, L-methylfolate and methylcobalamin B12.
Prime Vitality was created from real, lived experience. B12 and folate are in methylated forms and B6 and B2 in active forms, made in Britain in GMP-certified facilities. Basic forms like folic acid and cyanocobalamin have to be converted before your body can use them. We start with the forms your body can use straight away.
Basic forms like folic acid and cyanocobalamin cost very little to produce. Prime Vitality uses premium forms that cost more: methylcobalamin (B12), L-5-MTHF folate and P5P (B6), already in the state your body can use, and benfotiamine, a better-absorbed form of thiamine. You are paying for the form.
That is riboflavin, vitamin B2, and it is completely normal. Riboflavin is a naturally bright yellow-green pigment: its name comes from flavus, the Latin word for yellow. Ours is Riboflavin-5-Phosphate, the active form.
B vitamins are water soluble, so your body uses what it needs and passes the rest out rather than storing it. Riboflavin gives that a vivid yellow tint, usually within a few hours of taking your tablet. Doctors have a name for it, flavinuria, and it is harmless and well documented.
It is expected with any B-complex at a meaningful dose, and it is not a sign that anything is wrong. As with any supplement, if you have another symptom that concerns you, speak to your GP or pharmacist.
Take one tablet daily, ideally with a meal. Morning is a great time, as B vitamins contribute to normal energy-yielding metabolism throughout the day.
With a glass of water.
Breakfast or lunch is easiest.
Make it part of your routine, backed by our 90-day money-back guarantee.
Yes. Prime Vitality Methylated B Complex Ultra is fully vegan and non-GMO.
Yes. Every batch is manufactured in Britain, in facilities that are independently certified to recognised quality and food-safety standards.
Subscribe & Save delivers 3 bottles every 3 months at 40% off, which works out at 50p a day. You can skip, change or cancel any time from your account, and it is covered by the same 90-day money-back guarantee on your first ever order.
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