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A premium, high-strength methylated B complex, made in Britain. All eight B vitamins in their active forms, including the methylated forms of B12 and folate (methylcobalamin and L-methylfolate), plus P5P and benfotiamine, a fat-soluble derivative of thiamine with 11x the bioavailability of standard thiamine. Expertly formulated around the active forms studied in published research, by a proudly British company you can trust. One small tablet a day: vegan, non-GMO and gluten-free.
Serving Size: 1 Tablet · Servings per Container: 30
| Per Serving | %RI* | |
|---|---|---|
| Riboflavin (B2) as Riboflavin-5 Phosphate | 30 mg | 2,143% |
| Niacin (B3) as nicotinamide | 100 mg | 625% |
| Vitamin B6 as Pyridoxal 5-Phosphate | 10 mg | 713% |
| Methylfolate (B9) as L-5-Methyltetrahydrofolate | 667 µg | 334% |
| Methylcobalamin (B12) as methylcobalamin | 500 µg | 20,000% |
| Biotin as D-Biotin | 900 µg | 1,800% |
| Pantothenic Acid (B5) | 100 mg | 1,667% |
| Benfotiamine | 75 mg | ** |
| Inositol | 10 mg | ** |
| BioPerine® Black Pepper Extract providing 1.9 mg Piperine | 2 mg | ** |
*Reference Intake (RI) for an average adult **No RI established
Reference Intake (RI), also called the Nutrient Reference Value (NRV), is a single general figure for an average adult, set under UK food-labelling rules so products can be compared like for like. It reflects an amount considered enough for the great majority of healthy people rather than a personalised or optimal target, which is why supplement levels are often shown as a high percentage of the RI. Individual needs vary, so use the RI as a guide alongside a varied, balanced diet.
Suggested Use: Take 1 tablet daily, preferably with a meal.
Our active ingredients are backed by 200+ published clinical studies, including 135 randomised controlled trials and 29 meta-analyses. We choose every active for the research behind it, not because it is on trend. Here are a few of the studies on the B vitamins and active forms we use.
In the FACIT trial, 818 older adults took 800µg of folic acid every day for 3 years and scored on memory tests like people about 4.7 years younger than their age. Folate only helps if the body can use it, which is why we deliver it as L-5-MTHF (methylfolate), the active form, rather than folic acid. Folate contributes to normal psychological function.
Durga J et al. The Lancet, 2007.
In a double-blind trial, 129 healthy young adults took a daily supplement of nine vitamins for 12 months and reported better mood than those on placebo, most clearly among the women, with the improvement tracking their rising vitamin B2 and B6 status. We include B2 and B6, with folate and B12, in their active forms (R5P, P5P, methylfolate and methylcobalamin). B6, folate and B12 contribute to normal psychological function.
Benton D et al. Neuropsychobiology, 1995.
Benfotiamine is a fat-soluble derivative of thiamine (vitamin B1) that the body takes up more easily than standard thiamine hydrochloride. In a pharmacokinetic study in healthy volunteers it raised blood thiamine to around 11 times the level reached from thiamine hydrochloride, and roughly doubled the active coenzyme form in red blood cells. That superior absorption is why we chose it.
Xie F et al. J Clin Pharmacol, 2014.
In a double-blind trial, 215 healthy working men aged 30 to 55 took a high-dose B complex (with vitamin C and minerals) every day for 33 days. Compared with placebo, they rated themselves less mentally tired after demanding mental tasks and reported more vigour. Our formula is a high-dose B complex too, with B2, B3, B5, B6, folate and B12 in their active forms. Those six B vitamins contribute to the reduction of tiredness and fatigue.
Kennedy DO et al. Psychopharmacology, 2010.
Many people carry a common variation in the MTHFR gene that slows how they process folate. In a double-blind trial, 35 adults with this 677TT gene type took riboflavin (vitamin B2) at 1.6mg a day, or a placebo, for 12 weeks; homocysteine fell by about 22% across the riboflavin group and by as much as 40% in those who started with lower riboflavin levels. We include riboflavin as its active R5P form, alongside folate, B6 and B12. Folate, B6 and B12 contribute to normal homocysteine metabolism.
McNulty H et al. Circulation, 2006.
A meta-analysis pooling 25 randomised trials found folic acid lowered homocysteine by about 23%. We deliver folate (vitamin B9) as L-5-MTHF (methylfolate), the active form the body uses directly, without the conversion step folic acid needs. Folate contributes to normal homocysteine metabolism.
Homocysteine Lowering Trialists' Collaboration. Am J Clin Nutr, 2005.
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Published research on the B vitamins in our formula, which we provide in their active forms.
Backed by 200+ clinical studies
younger memory scores
in a 3-year folate trial
FACIT, double-blind, 818 adults
memoryIn the FACIT trial, 818 adults aged 50 to 70 with raised homocysteine took 800µg of folic acid every day for 3 years and scored on memory tests like people about 4.7 years younger. Our formula provides folate (vitamin B9) too, but as L-5-MTHF (methylfolate), the active form the body can use directly without first converting it. Folate contributes to normal psychological function.
FACIT trial · double-blind, randomised · Durga et al., The Lancet, 2007 · PMID 17240287
mood, over 12 months
in a double-blind vitamin trial
Benton et al., 1995, 129 adults
moodIn a double-blind trial, 129 healthy young adults took a daily supplement of nine vitamins, at ten times the recommended daily amounts, for 12 months. Those on the vitamins reported better mood than those on placebo, most clearly among the women, and the improvement tracked their rising vitamin B2 and B6 status. We include B2 and B6, with folate and B12, in their active forms: R5P, P5P, methylfolate and methylcobalamin. B6, folate and B12 contribute to normal psychological function.
Benton et al. · Neuropsychobiology, 1995 · double-blind, placebo-controlled · PMID 7477807
better absorbed
vs standard thiamine (vitamin B1)
Xie et al., 2014, pharmacokinetic study
energyBenfotiamine is a fat-soluble derivative of thiamine (vitamin B1) that the body takes up more easily than standard thiamine hydrochloride. In a pharmacokinetic study in healthy volunteers, it raised blood (plasma) thiamine to roughly 11 times the level reached from thiamine hydrochloride (a relative bioavailability of 1147%) and roughly doubled the active coenzyme form in red blood cells. That superior absorption is why we chose it.
Xie et al. · pharmacokinetic study, benfotiamine vs thiamine hydrochloride · 2014 · PMID 24399744
mental tiredness, after 33 days
in a high-dose B complex trial
Kennedy et al., 2010, double-blind, 215 men
energyIn a double-blind trial, 215 healthy working men aged 30 to 55 took a high-dose B complex (with vitamin C and minerals) every day for 33 days. Compared with placebo, they rated themselves less mentally tired after demanding mental tasks and reported more vigour. Our formula is a high-dose B complex too, with B2, B3, B5, B6, folate and B12 in their active forms. Those six B vitamins contribute to the reduction of tiredness and fatigue.
Kennedy et al. · Psychopharmacology, 2010 · double-blind, placebo-controlled · PMID 20454891
lower homocysteine
in adults with the common MTHFR gene type
McNulty et al., 2006, MTHFR 677TT
methylationLots of people carry a common variation in the MTHFR gene that slows how their body handles folate. In a double-blind trial, 35 adults with this 677TT gene type took riboflavin (vitamin B2) at 1.6mg a day, or a placebo, for 12 weeks. Homocysteine fell by about 22% across the riboflavin group, and by as much as 40% in those who started with lower riboflavin levels. We include riboflavin as its active R5P form, alongside folate, B6 and B12. Folate, B6 and B12 contribute to normal homocysteine metabolism.
McNulty et al. · Circulation, 2006 · double-blind · MTHFR 677TT adults · PMID 16380544
lower homocysteine
across 25 randomised trials
Homocysteine Lowering Trialists' Collaboration, 2005
methylationA meta-analysis pooling 25 randomised trials (2,596 people) found that folic acid lowered homocysteine by about 23% at a dose of 0.8mg a day. Our formula delivers folate (vitamin B9) as L-5-MTHF (methylfolate), the active form the body uses directly, without the conversion step folic acid needs. Folate contributes to normal homocysteine metabolism.
Homocysteine Lowering Trialists' Collaboration · meta-analysis of 25 randomised trials · American Journal of Clinical Nutrition, 2005 · PMID 16210710
Results from published clinical studies on the active nutrients and forms we use, not claims about the finished product. Food supplements are not a substitute for a varied, balanced diet and a healthy lifestyle.
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Rated 4.81 out of 5 by 216 customers
“I was tired most of the time. Taking this every morning I am not constantly tired anymore. A massive difference.”
“I had been feeling flat all the time. Since taking this my energy has picked up and I feel sharper, more like myself again.”
“These have become part of my daily routine and I feel really good for it. So pleased I found a quality B complex made in Britain.”
Produced in facilities independently certified to recognised quality and food-safety standards.
Prime Vitality only works with manufacturers held to the highest standards, so the quality you take every day is never left to chance.
Targeted nutrients. Authorised claims, in plain English.
Built from lived experience. Backed by better ingredients.
It started with a simple question: why do so many supplements promise the world but leave you feeling exactly the same?
After years of trying generic B-complex products and not feeling a difference, I set out to build a formula using the active, methylated forms of B vitamins your body can actually use.
Every batch is made in Britain to high quality standards, vegan, non-GMO, and designed for real life: one tablet, once a day.
Jackson, Founder
Targeted ingredients. Purposeful doses.
Premium, better-absorbed form.
Supports energy and normal skin.
Helps reduce tiredness and fatigue.
Supports mental performance.
Supports hormones and the nervous system.
Supports homocysteine metabolism.
Supports energy and focus.
Supports hair and skin.
A B-vitamin companion nutrient.
Patented piperine extract.
Simple. Daily. Consistent.
Take one tablet once daily.
Helps with absorption and reduces the chance of stomach upset.
Take one tablet every day and make it part of your routine, backed by our 90-day money-back guarantee.
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Methylated B vitamins are B vitamins supplied in the forms your body can use straight away, rather than forms it has to convert first. In this formula the two methylated forms are vitamin B12 as methylcobalamin and folate as L-5-MTHF methylfolate. Vitamin B6 is supplied as P-5-P and vitamin B2 as riboflavin-5-phosphate, which are active forms rather than methylated ones.
Methylated means the vitamins are in their active forms, which are easier for your body to recognise, absorb and use. Some people carry common gene variations that affect how efficiently they make that conversion.
Prime Vitality was created from real, lived experience. Every B vitamin is in an active, body-ready form, with B12 and folate as the methylated forms and made in Britain in GMP-certified facilities. Many brands use basic, non-active forms that your body has to convert before it can use them. We start with the forms your body can use straight away.
Cheaper supplements use non-active, basic forms that cost very little to produce. Prime Vitality uses premium active forms, like benfotiamine, methylcobalamin (B12), L-5-MTHF folate and P5P (B6), which cost more but are already in the state your body can use. You are paying for forms your body can actually use.
That is riboflavin, vitamin B2, and it is completely normal. Riboflavin is a naturally bright yellow-green pigment: its name comes from flavus, the Latin word for yellow. Ours is Riboflavin-5-Phosphate, the active form.
B vitamins are water soluble, so your body uses what it needs and passes the rest out rather than storing it. Riboflavin gives that a vivid yellow tint, usually within a few hours of taking your tablet. Doctors have a name for it, flavinuria, and it is harmless and well documented.
It is expected with any B-complex at a meaningful dose, and it is not a sign that anything is wrong. As with any supplement, if you have another symptom that concerns you, speak to your GP or pharmacist.
Take one tablet daily, ideally with a meal. Morning is a great time, as B vitamins contribute to normal energy-yielding metabolism throughout the day.
Take one tablet once daily.
Helps with absorption and reduces the chance of stomach upset.
For best results, use daily for at least 3 months.
Yes. Prime Vitality Methylated B Complex Ultra is fully vegan and non-GMO.
Yes. Every batch is manufactured in Britain, in facilities that are independently certified to recognised quality and food-safety standards.
Subscribe & Save delivers 3 bottles every 3 months at 40% off, which works out at 50p a day. You can skip, change or cancel any time from your account, and it is covered by the same 90-day money-back guarantee on your first ever order.
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