The Best Methylated B Complex Supplements in the UK, Compared (October 2026)
A methylated B complex gives you the active, body-ready forms of the B vitamins. But they are not all equal. Here are five UK options compared on their labels, what separates them, and where our own Methylated B Complex Ultra fits. It is our product, so we say so up front.
A great methylated B complex uses the methylated forms of both B12 and folate, not just one of them.
- The best methylated B complex uses methylated B12 and folate together, not just methylfolate on its own.
- Our own formula is Prime Vitality Methylated B Complex Ultra, our methylated B vitamins: methylated B12 and folate, B6 as P5P and B2 as riboflavin-5-phosphate, plus benfotiamine, inositol and BioPerine, in one daily tablet, made in Britain.
- Check the label before you buy: some complexes marketed as "methylated" use folic acid rather than L-5-MTHF methylfolate, so look for L-5-MTHF.
- Lamberts and Igennus are excellent methylated options too. Budget and high-street complexes are cheaper but usually use standard forms like folic acid and cyanocobalamin.
- For folate, the active form (methylfolate) is the one that matters most, because it skips the MTHFR conversion step.
What makes a methylated B complex worth buying?
Look for methylated B12 and folate, active B6 and B2, meaningful doses, an honest label with no proprietary blends, and manufacturing to recognised UK standards.
"Methylated" simply means a vitamin is supplied in its active, body-ready form, carrying the methyl group your body would otherwise have to add itself.1 The trouble is that many products labelled "methylated" only use the active form for one or two nutrients (usually folate) and fall back to cheaper standard forms for the rest. We judged each product on five things:
- Active forms where they matter: methylcobalamin (B12), L-5-MTHF (folate), P5P (B6), riboflavin-5-phosphate (B2) and, ideally, benfotiamine.
- A complete complex: the full B complex, not a partial blend.
- Meaningful, sensible doses you can actually see on the label.
- Transparency: every ingredient and amount listed, with no hidden "blends".
- Quality and value: made to UK GMP standards, suitable for vegans, and fairly priced, ideally with a guarantee.
The 5 best methylated B complex supplements (UK)
1. Prime Vitality Methylated B Complex Ultra Our own formula
Methylated B12 and folate, B6 as P5P and B2 as riboflavin-5-phosphate, plus benfotiamine, inositol and BioPerine, in one tablet a day. Made in Britain, fully transparent, and backed by a money-back guarantee.
Per tablet: methylfolate (L-5-MTHF) 667mcg, methylcobalamin (B12) 500mcg, P5P (active B6) 10mg, riboflavin-5-phosphate (active B2) 30mg and benfotiamine 75mg, plus niacin, pantothenic acid and D-biotin. Rated 4.81 out of 5 by 218 customers.
This is our own formula, so treat this as our informed and transparent view rather than an independent test (more on that below). We built it around the checklist above. It uses methylcobalamin (B12), L-5-MTHF folate, P5P (B6) and riboflavin-5-phosphate (B2), and adds benfotiamine, a fat-soluble derivative of thiamine. Because it is fat-soluble rather than water-soluble, benfotiamine is absorbed more readily and has been shown to raise blood levels of thiamine markedly more than standard B1, which is why we use it in place of ordinary thiamine.4 Every amount is printed on the label, it is vegan, non-GMO and made in a UK facility to GMP standards, and it comes with a money-back guarantee and a subscribe-and-save option.
Best for: anyone who wants methylated B12 and folate alongside active B6 and B2 in a single daily tablet, with nothing hidden. Watch-outs: as a premium active formula it is not the cheapest per tablet, and it is sold direct rather than on the high street.
2. Lamberts Methyl B Complex Heritage UK brand
A genuinely well-formulated methylated complex from a respected UK practitioner brand, using methylfolate, P5P and methylcobalamin.
Lamberts is a long-established British supplement brand, and its Methyl B Complex uses methylfolate (as Quatrefolic), pyridoxal-5-phosphate (P5P) and methylcobalamin rather than the cheaper standard forms.5 It is a strong, trustworthy option. The clearest formula difference from our pick is benfotiamine, the fat-soluble derivative of thiamine that absorbs better and raises blood thiamine further than standard B1;4 we include it, and it is not listed in the Lamberts formula. Our formula also adds inositol and BioPerine, plus a money-back guarantee and subscription pricing. If you want a methylated complex from a heritage name, this is an excellent choice.
3. Igennus Super B-Complex Sustained release
A science-led, vegan methylated complex with sustained-release technology, designed to release the B vitamins gradually.
Igennus formulates with bioactive, methylated forms, including methylfolate, methylcobalamin and P5P, and uses a sustained-release delivery in small tablets, manufactured to UK GMP.6 It is a well-made, thoughtfully designed product. It typically uses a smaller per-dose approach taken across the day rather than a single one-a-day tablet, so the right choice here comes down to whether you prefer sustained release or a simple once-daily dose.
4. Nu U Nutrition Vitamin B Complex Best value all-rounder
A complete B complex at a budget-friendly price, often with around a six-month supply per bottle.
If your priority is covering the full B complex cheaply, a value brand like Nu U Nutrition does the job and lasts a long time per bottle. The trade-off with most budget complexes is the forms: they tend to use standard folic acid and cyanocobalamin rather than the active, methylated versions, so if methylation is the reason you are shopping, check the label carefully before buying.
5. A standard high-street B complex Simple top-up
The own-brand or pharmacy B complex you can pick up anywhere. Cheap and convenient, but usually built on standard forms.
Most supermarket and pharmacy B complexes use folic acid, cyanocobalamin and pyridoxine at modest doses. For a lot of people with a varied diet, that is perfectly fine.1 They are the cheapest and most convenient option. They are simply not the right pick if you specifically want the active forms with methylated B12 and folate, or higher, clearly-stated doses.
At a glance
| Product | Methylated B12 and folate | Benfotiamine | Made in Britain | Best for |
|---|---|---|---|---|
| Prime Vitality Methylated B Complex Ultra | ✓ | ✓ | ✓ | One a day, with benfotiamine |
| Lamberts Methyl B Complex | Not listed | ✓ | ✓ | Heritage brand |
| Igennus Super B-Complex | Not listed | ✓ | ✓ | Sustained release |
| Nu U Nutrition B Complex | Usually standard | Not listed | Check label | Budget value |
| Standard high-street complex | Standard forms | Not listed | Varies | Cheap, convenient |
Comparison based on publicly listed formulations, checked 16 October 2026. Always check the current label.
How the labels compare
It’s the form that matters.
Label check, 16 October 2026: Prime Vitality Methylated B Complex Ultra lists methylcobalamin (B12), L-methylfolate (folate), P5P (B6), riboflavin-5-phosphate (B2) and benfotiamine in one tablet a day. The table shows what the 8 best-selling B complexes on Amazon UK, plus the Holland and Barrett and Boots own-brand B complexes, list for the same nutrients.
| Label check |  Prime VitalityMethylated B Complex Ultra | Holland & BarrettHigh Strength Complete Vit B Complex | BootsVitamin B Complex | IgennusSuper B-Complex | WeightWorldVitamin B Complex | New LeafVitamin B Complex | SolgarB-Complex “50” | BetterYouB-Complete Oral Spray | HorbäachVitamin B Complex | SolgarB-Complex “100” | BioCareMethyl B Complex |
|---|---|---|---|---|---|---|---|---|---|---|---|
One a dayOne tablet or capsule | Yes | No2 tablets | Yes | No2 tablets | Yes | Yes | Yes | No4 sprays | Yes | Yes | Yes |
BenfotiamineFat-soluble form of thiamine, better absorbed* | Yes | NoThiamine | NoThiamine | NoThiamine | NoThiamine | NoThiamine | NoThiamine | NoThiamine | NoThiamine | NoThiamine | NoThiamine |
30 mg of active B2 a dayRiboflavin-5-phosphate | Yes | No15 mg (not the active form) | No1.4 mg (not the active form) | No14 mg | No7 mg (not the active form) | No5 mg (not the active form) | No50 mg (not the active form) | No0.35 mg | No1.4 mg (not the active form) | No100 mg (not the active form) | No25 mg |
Active B6P5P, not pyridoxine | Yes | NoPyridoxine | NoPyridoxine | Yes | NoPyridoxine | NoPyridoxine | NoPyridoxine | NoPyridoxine | NoPyridoxine | NoPyridoxine | Yes |
100 mg of B5 a dayPantothenic acid | Yes | Yes | No6 mg | No36 mg | No20 mg | No9.2 mg | No50 mg | No4.5 mg | No6 mg | Yes | No25 mg |
Methylated folateL-methylfolate, not folic acid | Yes | NoFolic acid | NoFolic acid | Yes | NoFolic acid | NoFolic acid | NoFolic acid | NoFolic acid | NoFolic acid | NoFolic acid | Yes |
900 µg of biotin a day | Yes | No100 µg | No50 µg | No300 µg | No150 µg | No150 µg | No50 µg | No50 µg | No50 µg | No100 µg | No200 µg |
Swipe to compare 10 brands →
The eight best-selling B complexes on Amazon UK, plus the own-brand B complexes of Holland & Barrett and Boots, compared using each brand’s own label and website, checked 16 October 2026. Figures per daily serving. “Not the active form” means riboflavin rather than riboflavin-5-phosphate. *Benfotiamine is better absorbed than standard thiamine (Xie et al., 2014).
Choose my planFor the wider picture, see our label study of 49 UK B complexes, or check any label with our free label checker.
Where Prime Vitality fits
The shortlist is genuinely strong, Lamberts and Igennus in particular. Ours is built for people who want methylated B12 and folate, with B6 as P5P, B2 as riboflavin-5-phosphate and benfotiamine, in one daily tablet, with every amount on the label. It is made in Britain, vegan and non-GMO, with a 90-day money-back guarantee. If you prefer a heritage practitioner brand or sustained release, Lamberts or Igennus may suit you better.
Most "methylated" complexes get one or two nutrients right. The goal with Methylated B Complex Ultra was to get all of them right in a single daily tablet, and to print every amount on the label so you can check it yourself.
How to choose the right one for you
If you want methylated B12 and folate with active B6 and B2 in one daily tablet, ours is built for that. If you prefer a heritage practitioner brand, Lamberts is excellent. If you like the idea of sustained release, look at Igennus. If budget is the priority and you are happy with standard forms, a value or high-street complex will cover the basics. Whichever you choose, the single most important active form to look for is methylfolate rather than folic acid.2
Frequently asked questions
What is the best methylated B complex in the UK?
It depends on what you want. If you want methylated B12 and folate with active B6 and B2 and benfotiamine in one daily tablet, our own Methylated B Complex Ultra is built for that. Lamberts Methyl B Complex suits people who prefer a heritage practitioner brand, and Igennus Super B-Complex suits those who like sustained release. Whichever you choose, look for methylfolate (L-5-MTHF) rather than folic acid.
Is a methylated B complex worth it?
For folate it can genuinely matter, because methylfolate skips the MTHFR conversion step. For the other B vitamins, "active" mainly means body-ready rather than dramatically better absorbed. If a methylated complex is similar in price to a standard one, choosing the active forms is a reasonable decision.2
How does Prime Vitality compare with Lamberts and Igennus?
All three are methylated complexes made in Britain. Ours puts methylated B12 and folate, B6 as P5P, B2 as riboflavin-5-phosphate and benfotiamine in one daily tablet, with every amount on the label and a 90-day money-back guarantee. Lamberts is a heritage practitioner brand, and Igennus uses sustained release. The right pick depends on your preferences.
How do the labels compare?
Label check, 16 October 2026: Prime Vitality Methylated B Complex Ultra lists methylcobalamin (B12), L-methylfolate (folate), P5P (B6), riboflavin-5-phosphate (B2) and benfotiamine in one tablet a day. The table shows what the 8 best-selling B complexes on Amazon UK, plus the Holland and Barrett and Boots own-brand B complexes, list for the same nutrients.
What should I look for on the label?
Look for methylcobalamin (B12), L-5-MTHF or methylfolate (folate), P5P (B6) and riboflavin-5-phosphate (B2), ideally benfotiamine, the full B complex, clearly stated amounts, and no proprietary blends.
Which methylated B complex is best for MTHFR?
If you are aware of an MTHFR variant, the form of folate matters most: look for methylfolate (L-5-MTHF) rather than folic acid, because methylfolate is already the active form and does not depend on the MTHFR conversion step. Lamberts, Igennus and our own formula all use methylfolate, alongside methylcobalamin (B12) and P5P (B6). This is general information, not medical advice.
How we compared these, and our interest
We make one of these products (listed first), so this is our informed, transparent opinion rather than an independent lab test. We have tried to be specific and fair, to give real credit to the other brands, and to base every comparison on publicly available formulations as checked on 16 October 2026. Formulations and prices change, so always check the current label before you buy. This article is general information, not medical advice. Food supplements are not a substitute for a varied, balanced diet and a healthy lifestyle.
References
- NHS. B vitamins and folic acid.
- NIH Office of Dietary Supplements. Folate Fact Sheet for Health Professionals.
- NIH Office of Dietary Supplements. Vitamin B12 Fact Sheet for Health Professionals.
- Loew D. Pharmacokinetics of thiamine derivatives, especially benfotiamine. Int J Clin Pharmacol Ther, 1996.
- Lamberts Healthcare. Methyl B Complex (product information).
- Igennus Healthcare Nutrition. Super B-Complex (product information).
Active B vitamins your body can use straight away
Methylated forms, clear labelling, Made in Britain.
Shop Now →
