More energy. Less tiredness. B vitamins that work.

From middle age onwards, memory scores tend to drift down year on year, and that steady decline is exactly what the FACIT researchers measured against. In that trial, 818 adults aged 50 to 70 with raised homocysteine took 800µg of folic acid every day for three years, and finished ahead of the placebo group by roughly what 4.7 years of that decline would have cost them. Put simply: on those tests, their memory performed as though it were 4.7 years younger. Our formula provides folate (vitamin B9) too, but as L-5-MTHF (methylfolate), the active form the body can use directly without first converting it. Folate contributes to normal psychological function.

FACIT trial · double-blind, randomised · Durga et al., The Lancet, 2007 · PMID 17240287

In a double-blind trial, 129 healthy young adults took a daily supplement of nine vitamins, at ten times the recommended daily amounts, for 12 months. Those on the vitamins reported better mood than those on placebo, most clearly among the women, and the improvement tracked their rising vitamin B2 and B6 status. We include B2 and B6, with folate and B12, in their active forms: R5P, P5P, methylfolate and methylcobalamin. B6, folate and B12 contribute to normal psychological function.

Benton et al. · Neuropsychobiology, 1995 · double-blind, placebo-controlled · PMID 7477807

Benfotiamine is a fat-soluble derivative of thiamine (vitamin B1) that the body takes up more easily than standard thiamine hydrochloride. In a pharmacokinetic study in healthy volunteers, it raised blood (plasma) thiamine to roughly 11 times the level reached from thiamine hydrochloride (a relative bioavailability of 1147%) and roughly doubled the active coenzyme form in red blood cells. That superior absorption is why we chose it.

Xie et al. · pharmacokinetic study, benfotiamine vs thiamine hydrochloride · 2014 · PMID 24399744

In a double-blind trial, 215 healthy working men aged 30 to 55 took a high-dose B complex (with vitamin C and minerals) every day for 33 days. Compared with placebo, they rated themselves less mentally tired after demanding mental tasks and reported more vigour. Our formula is a high-dose B complex too, with B2, B3, B5, B6, folate and B12 in their active forms. Those six B vitamins contribute to the reduction of tiredness and fatigue.

Kennedy et al. · Psychopharmacology, 2010 · double-blind, placebo-controlled · PMID 20454891

Why a high reading is worth knowing about. Homocysteine is what is left over when your body runs methylation, the reaction it uses to build and repair everything from DNA to brain chemistry. Folate, B12 and B6 normally recycle that leftover straight back into something useful. When those vitamins run short the recycling stalls and homocysteine builds up in the blood, which is why a raised reading is treated as one of the clearest signs that someone's folate and B12 status is poor. Bringing it down is the sign that the cycle is turning over properly again. Lots of people also carry a common variation in the MTHFR gene that slows how their body handles folate. In a double-blind trial, 35 adults with this 677TT gene type took riboflavin (vitamin B2) at 1.6mg a day, or a placebo, for 12 weeks. Homocysteine fell by about 22% across the riboflavin group, and by as much as 40% in those who started with lower riboflavin levels. We include riboflavin as its active R5P form, alongside folate, B6 and B12. Folate, B6 and B12 contribute to normal homocysteine metabolism.

McNulty et al. · Circulation, 2006 · double-blind · MTHFR 677TT adults · PMID 16380544

Why a high reading is worth knowing about. Homocysteine is the leftover from methylation, the reaction your body uses to build and repair DNA and brain chemistry. Folate, B12 and B6 recycle that leftover back into something useful, so when they run short it builds up. That is why a raised reading is one of the clearest signs that folate and B12 status is poor, and why bringing it down shows the cycle has what it needs again. A meta-analysis pooling 25 randomised trials (2,596 people) found that folic acid lowered homocysteine by about 23% at a dose of 0.8mg a day. Our formula delivers folate (vitamin B9) as L-5-MTHF (methylfolate), the active form the body uses directly, without the conversion step folic acid needs. Folate contributes to normal homocysteine metabolism.

Homocysteine Lowering Trialists' Collaboration · meta-analysis of 25 randomised trials · American Journal of Clinical Nutrition, 2005 · PMID 16210710